Last update
5/29/2025

Overview

SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%

Top Medical Research Studies

9
Folic acid improves heart function
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.

However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
8
Folate intake reduces heart disease risk
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.

After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.

However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.

While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.

Most Useful Reviews

9
Reduces palpitations
1 people found this helpful
It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.
9
Reduces heart attack risk
Folic acid, a vitamin B, is necessary for DNA construction in body cells. It is vital for our immunity, cardiovascular health, and metabolism due to its role in amino acid synthesis. This substance bolsters blood vessel walls and supports heart health, thus lowering the risk of heart attack. It is also essential for proper nervous system function, influencing psychological mood and performance. It’s important to note that natural sources do not substitute for tablet form, as absorption is better with pills.
6
Improves heart function
287 people found this helpful
The last time I purchased this supplement, which comes in gelatin capsules, I couldn't immediately assess the difference. I take it to support my heart and appreciate its effect. I did try increasing the dosage, but it made my heartbeat feel erratic. I am grateful to iHerb and those who leave reviews, as they significantly help me make informed choices regarding supplements when medical professionals may not always offer adequate advice.

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
  • All Researches
9
Folic acid improves heart function
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.

However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
9
Exosomes enhance heart recovery post-MI
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.

Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.

This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
8
Folate intake reduces heart disease risk
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.

After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.

However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.

While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
We examined the link between multivitamin use, including folic acid, and the risk of heart attacks in women. Our study followed 31,671 women without heart disease and evaluated their supplement usage over ten years.

We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.

More research is needed to fully understand these results and confirm our findings.

User Reviews

USERS' SCORE
Moderately Good
Based on 10 Reviews
7.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduces palpitations
1 people found this helpful
It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.
9
Reduces heart attack risk
Folic acid, a vitamin B, is necessary for DNA construction in body cells. It is vital for our immunity, cardiovascular health, and metabolism due to its role in amino acid synthesis. This substance bolsters blood vessel walls and supports heart health, thus lowering the risk of heart attack. It is also essential for proper nervous system function, influencing psychological mood and performance. It’s important to note that natural sources do not substitute for tablet form, as absorption is better with pills.
6
Improves heart function
287 people found this helpful
The last time I purchased this supplement, which comes in gelatin capsules, I couldn't immediately assess the difference. I take it to support my heart and appreciate its effect. I did try increasing the dosage, but it made my heartbeat feel erratic. I am grateful to iHerb and those who leave reviews, as they significantly help me make informed choices regarding supplements when medical professionals may not always offer adequate advice.
7.5
Promotes heart health
1 people found this helpful
Very beneficial for heart health; I take one daily as recommended. It's a quality product with a good quantity.
7.5
Crucial for blood formation
Vitamin B9 is essential for processes like cell growth and maintaining DNA integrity; deficiencies can result in tumour formation. It supports the immune system, heart, blood vessels, and amino acid synthesis. Folic acid benefits the nervous system, impacting mood and performance, while also being critical for blood formation. As prescribed, this supplement addresses my concerns effectively.

Frequently Asked Questions

6
Improves heart function
287 people found this helpful
The last time I purchased this supplement, which comes in gelatin capsules, I couldn't immediately assess the difference. I take it to support my heart and appreciate its effect. I did try increasing the dosage, but it made my heartbeat feel erratic. I am grateful to iHerb and those who leave reviews, as they significantly help me make informed choices regarding supplements when medical professionals may not always offer adequate advice.
6
Improves mood stability
1 people found this helpful
My husband noticed that during heavy exertion at the gym, he experienced a strong heartbeat. The trainer advised trying this supplement. After a course, the heart’s reaction to exercise improved. He also found that severe mood swings diminished, and the pills had a calming effect on the nervous system.
9
Reduces palpitations
1 people found this helpful
It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.
7.5
Reduces heart attack risk
1 people found this helpful
The tablets are small and easy to take. They promote new cell formation, helping my skin appear smooth and healthy, and improving the thickness and shine of my hair, as well as nail strength. Folic acid contributes to normal heart function and reduces the risk of a heart attack. With regular supplementation, a woman can maintain her youthfulness longer. I recommend it!
9
Reduces heart attack risk
Folic acid, a vitamin B, is necessary for DNA construction in body cells. It is vital for our immunity, cardiovascular health, and metabolism due to its role in amino acid synthesis. This substance bolsters blood vessel walls and supports heart health, thus lowering the risk of heart attack. It is also essential for proper nervous system function, influencing psychological mood and performance. It’s important to note that natural sources do not substitute for tablet form, as absorption is better with pills.
7.5
High-folic acid source
5 people found this helpful
Folic acid is an essential part of my daily routine, and I’m very pleased with the iHerb product. Taking 800 mcg daily promotes heart health, boosts immunity, and benefits skin health. The product came well-packaged and safe. The tablets are easy to swallow, with no unpleasant taste. I feel confident that I'm receiving the necessary nutrients for my well-being.
8
Folate intake reduces heart disease risk
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.

After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.

However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
We investigated how folic acid (FA) might safeguard against heart damage induced by isoprenaline (ISO) in rats. Adult male Wistar albino rats received FA pretreatment for seven days before ISO was administered to mimic heart injury.

Our results showed that FA pretreatment helped reduce harmful markers indicating heart damage and oxidative stress. Specifically, FA lowered levels of homocysteine and improved antioxidant enzyme activities, suggesting a protective effect.

Ultimately, while FA demonstrated some benefits in this model, further research is needed to assess its real-world applications for heart health.
4
Folic acid shows modest stroke benefit
We aimed to determine the effectiveness of folic acid in preventing cardiovascular disease (CVD) through an updated meta-analysis of 26 randomized controlled trials involving nearly 59,000 participants. Our findings revealed that folic acid supplementation did not significantly impact the risk of CVD, coronary heart disease, or overall mortality.

Interestingly, there was a slight trend showing potential stroke risk reduction, although results were not conclusive. Overall, while supplementation may carry some modest benefits for stroke prevention, it does not appear to significantly reduce the risk of heart-related issues.
9
Folic acid improves heart function
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.

However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
We pooled data from two randomized controlled trials in Norway, which involved nearly 7,000 patients with ischaemic heart disease. Participants received daily doses of folic acid, vitamin B12, and other B vitamins, with a parallel group receiving a placebo.

After a thorough follow-up, we observed that there were no significant benefits of folic acid on heart attacks or other major cardiovascular events. This suggests that improving homocysteine levels through B-vitamins might not be an effective strategy for reducing heart-related risks.

References

  1. Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. 10.1088/2057-1976/ad40b2
  2. Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. 10.1556/2060.2023.00291
  3. Zhang B, Dong H, Xu Y, Xu D, Sun H, et al. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort. Eur J Clin Nutr. 2023;77:299. 10.1038/s41430-022-01206-2
  4. Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, et al. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Ann Intern Med. 2019;171:190. 10.7326/M19-0341
  5. Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. 10.1111/joim.12834
  6. Li H, Gao J, Shang Y, Hua Y, Ye M, et al. Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction. ACS Appl Mater Interfaces. 2018;10:24459. 10.1021/acsami.8b08659
  7. Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612. 10.1002/14651858.CD006612.pub5
  8. Kagawa Y, Hiraoka M, Kageyama M, Kontai Y, Yurimoto M, et al. Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification. Congenit Anom (Kyoto). 2017;57:157. 10.1111/cga.12215
  9. Nigwekar SU, Kang A, Zoungas S, Cass A, Gallagher MP, et al. Interventions for lowering plasma homocysteine levels in dialysis patients. Cochrane Database Syst Rev. 2016;2016:CD004683. 10.1002/14651858.CD004683.pub4
  10. Söderström E, Eliasson M, Johnson O, Hallmans G, Weinehall L, et al. Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population. Lipids Health Dis. 2013;12:74. 10.1186/1476-511X-12-74
  11. Yang HT, Lee M, Hong KS, Ovbiagele B, Saver JL. Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials. Eur J Intern Med. 2012;23:745. 10.1016/j.ejim.2012.07.004
  12. Mujibul Haq AM, M Giasuddin AS, Huque MM. Serum total homocysteine and lipoprotein (a) levels in acute myocardial infarction and their response to treatment with vitamins. J Coll Physicians Surg Pak. 2011;21:266.
  13. Rautiainen S, Akesson A, Levitan EB, Morgenstern R, Mittleman MA, et al. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr. 2010;92:1251. 10.3945/ajcn.2010.29371
  14. Qipshidze N, Tyagi N, Sen U, Givvimani S, Metreveli N, et al. Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;299:H1484. 10.1152/ajpheart.00577.2010
  15. Ebbing M, Bønaa KH, Arnesen E, Ueland PM, Nordrehaug JE, et al. Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J Intern Med. 2010;268:367. 10.1111/j.1365-2796.2010.02259.x
  16. Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, et al. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA. 2010;303:2486. 10.1001/jama.2010.840
  17. Ni Y, Hua Y, He Z, Hu W, Chen Z, et al. Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction. J Biomater Appl. 2024;39:139. 10.1177/08853282241251610
  18. An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. 10.1016/j.jacc.2022.09.048
  19. Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
  20. Twum F, Morte N, Wei Y, Nkemjika S, Liu F, et al. Red blood cell folate and cardiovascular deaths among hypertensive adults, an 18-year follow-up of a national cohort. Hypertens Res. 2020;43:938. 10.1038/s41440-020-0482-5
  21. Saad Shaukat MH, Toledo-Garcia A, Torosoff M. Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C). Cureus. 2019;11:e5344. 10.7759/cureus.5344
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