Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice.
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
8
Folate intake reduces heart disease risk
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
Folic acid fortification reduces costs
Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification.
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
Most Useful Reviews
9
Reduces palpitations
1 people found this helpful
It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.
Read More
9
Reduces heart attack risk
Folic acid, a vitamin B, is necessary for DNA construction in body cells. It is vital for our immunity, cardiovascular health, and metabolism due to its role in amino acid synthesis. This substance bolsters blood vessel walls and supports heart health, thus lowering the risk of heart attack. It is also essential for proper nervous system function, influencing psychological mood and performance. It’s important to note that natural sources do not substitute for tablet form, as absorption is better with pills.
Read More
6
Improves heart function
287 people found this helpful
The last time I purchased this supplement, which comes in gelatin capsules, I couldn't immediately assess the difference. I take it to support my heart and appreciate its effect. I did try increasing the dosage, but it made my heartbeat feel erratic. I am grateful to iHerb and those who leave reviews, as they significantly help me make informed choices regarding supplements when medical professionals may not always offer adequate advice.
Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice.
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
9
Exosomes enhance heart recovery post-MI
Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction.
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Read More
8
Folate intake reduces heart disease risk
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
Folic acid fortification reduces costs
Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification.
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
8
Multivitamins may reduce heart attack risk
Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women.
We examined the link between multivitamin use, including folic acid, and the risk of heart attacks in women. Our study followed 31,671 women without heart disease and evaluated their supplement usage over ten years.
We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.
More research is needed to fully understand these results and confirm our findings.
It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.
Read More
9
Reduces heart attack risk
Folic acid, a vitamin B, is necessary for DNA construction in body cells. It is vital for our immunity, cardiovascular health, and metabolism due to its role in amino acid synthesis. This substance bolsters blood vessel walls and supports heart health, thus lowering the risk of heart attack. It is also essential for proper nervous system function, influencing psychological mood and performance. It’s important to note that natural sources do not substitute for tablet form, as absorption is better with pills.
Read More
6
Improves heart function
287 people found this helpful
The last time I purchased this supplement, which comes in gelatin capsules, I couldn't immediately assess the difference. I take it to support my heart and appreciate its effect. I did try increasing the dosage, but it made my heartbeat feel erratic. I am grateful to iHerb and those who leave reviews, as they significantly help me make informed choices regarding supplements when medical professionals may not always offer adequate advice.
Read More
7.5
Promotes heart health
1 people found this helpful
Very beneficial for heart health; I take one daily as recommended. It's a quality product with a good quantity.
Read More
7.5
Crucial for blood formation
Vitamin B9 is essential for processes like cell growth and maintaining DNA integrity; deficiencies can result in tumour formation. It supports the immune system, heart, blood vessels, and amino acid synthesis. Folic acid benefits the nervous system, impacting mood and performance, while also being critical for blood formation. As prescribed, this supplement addresses my concerns effectively.
A heart attack, also known as myocardial infarction, occurs when blood flow to a part of the heart is blocked, often by a blood clot. This interruption can damage or destroy part of the heart muscle, leading to serious health complications or death if not treated promptly. Common symptoms include chest pain, shortness of breath, nausea, and lightheadedness. Risk factors include high blood pressure, high cholesterol, smoking, diabetes, and a sedentary lifestyle.
Preventing a heart attack largely revolves around maintaining a heart-healthy lifestyle. Regular exercise, a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, along with managing stress, can significantly lower the risk. Furthermore, understanding your personal risk factors and engaging with healthcare professionals for regular check-ups can be crucial in both prevention and early detection. If you suspect someone is having a heart attack, it's important to call emergency services immediately, as timely treatment is vital for survival and recovery.
Folic acid, also known as vitamin B9, is a water-soluble vitamin that plays a crucial role in many bodily functions, particularly in the synthesis of DNA and RNA. It is essential for cell division and is especially important during periods of rapid growth, such as during pregnancy and infancy. The body cannot produce folic acid on its own, which is why it must be obtained from dietary sources or supplements. Commonly found in leafy green vegetables, legumes, seeds, and fortified foods, folic acid is vital for preventing neural tube defects in developing fetuses and is often recommended for women of childbearing age.
In addition to its key role in pregnancy, folic acid contributes to the production of red blood cells and can help reduce the risk of certain types of anemia. Research has also suggested that adequate folic acid levels may be associated with lowered risk of heart disease and other health issues. Most health organizations recommend a daily intake of 400 micrograms for adults, with higher amounts suggested for pregnant women. Incorporating folate-rich foods into your diet, or considering supplementation, can help ensure you meet your folic acid needs.
Folic acid, a B vitamin, is known primarily for its role in DNA synthesis and repair, as well as its importance during pregnancy. Its impact on heart health, particularly in the prevention of heart attacks, has been a topic of extensive research. Some studies suggest that folic acid may help to lower homocysteine levels in the blood, which is a potential risk factor for cardiovascular diseases. Lowering homocysteine levels could theoretically reduce the risk of heart attacks, but evidence from clinical trials has yielded mixed results. While some trials have shown a slight benefit, many large-scale studies have concluded that folic acid supplementation does not significantly reduce the risk of heart attacks.
Ultimately, while maintaining adequate folic acid levels as part of a balanced diet is essential for overall health, relying solely on folic acid to prevent heart attacks is not advisable. Instead, focusing on a comprehensive approach to heart health that includes a balanced diet rich in fruits, vegetables, whole grains, physical activity, and other lifestyle changes is more effective. As always, it's best to consult with a healthcare professional before starting any new supplementation, especially if you're concerned about heart health.
Based on user reviews, the timeline for noticing results from this supplement can vary. Some users report that they did not immediately notice a difference, highlighting that effects may not be instant. For instance, one user mentioned they couldn't assess the difference right away after starting the supplement, although they did appreciate its overall effects on heart support over time Read Review. Another user shared experiences of improved heart reactions during exertion after a course of the supplement, suggesting that gradual benefits can be expected with consistent use Read Review.
Overall, while some users reported tangible improvements related to heart health and mood after approximately a month of regular supplementation, others may find the effects take longer to manifest. It’s worth noting that individuals react differently and the timing for noticeable changes could depend on personal health conditions, dosage, and overall lifestyle. In summary, many users suggest allowing a significant amount of time, often several weeks to a few months, to fully appreciate the benefits of this supplement.
While folic acid has been investigated for its potential benefits in heart health, the results of various studies present a mixed picture regarding its effectiveness specifically for heart attack prevention. On one hand, research suggests that higher dietary intake of folate is associated with a reduction in overall cardiovascular risks, including coronary heart disease [3]. Additionally, folic acid has shown promise in protecting against heart damage in experimental models, such as reducing harmful markers in rat studies [2]. However, many clinical trials have demonstrated that folic acid supplementation does not significantly decrease the incidence of heart attacks, with one extensive meta-analysis indicating no conclusive benefits in preventing cardiovascular events overall [11].
Furthermore, while some studies hint at folic acid potentially having a supportive role in heart recovery post-heart attack [14], its preventive effects against heart attacks remain inconclusive. For instance, a study examining large groups of patients found no significant benefits of vitamin B treatments, including folic acid, in altering heart attack risks [15]. Therefore, while there is some evidence that folic acid may have indirect benefits for heart health, its role as a definitive preventive measure against heart attacks is not strongly supported by current research.
Users have reported notable improvements in a variety of symptoms attributed to the supplement. Several individuals, for instance, mentioned significant reductions in heart palpitations and irritability, with one specific user stating that their wife's irritability had markedly decreased along with her hot flashes Read Review. Additionally, both heart health and mood enhancements were frequently highlighted, with users observing smoother heart reactions during physical exertion and a decrease in mood swings. One review specifically noted the calming effect on the nervous system, which contributed to an overall feeling of well-being Read Review.
Moreover, the supplement is noted for its beneficial effects on skin and hair, with a user describing improved skin smoothness and hair thickness alongside an increase in overall vitality Read Review. While many users report these positive outcomes, it is also important to acknowledge that individual results may vary significantly based on health conditions, dosage, and lifestyle choices. As with any supplement, what works for one person may not yield the same effects for another.
Users report varied experiences with combining this supplement with other products for heart health, particularly when handling concerns like heart attack risks. Some individuals mention taking folic acid alongside other vitamins, emphasizing its importance in supporting cardiovascular health. For example, one user highlights that adequate folic acid intake is crucial as it bolsters blood vessel walls and thus lowers heart attack risks, making it an essential part of their regimen Read Review. Another user expresses confidence in their routine that includes daily folic acid as part of a daily health regimen, which promotes heart health while also benefiting skin and immunity Read Review.
However, caution is advised when increasing the dosage, as one user noted that higher amounts led to an erratic heartbeat, indicating that fine-tuning supplementation may be necessary based on individual responses Read Review. Overall, while many users report positive outcomes when combining folic acid with other supplements for heart health, experiences can vary, suggesting that personal health circumstances should guide dosage and combination choices.
Users report varying experiences regarding the appropriate dosage of Folic Acid for heart health. Many have found success with a daily intake of 800 mcg, citing benefits such as improved heart health, reduced irritability, and enhanced overall well-being Read Review. However, some users caution against increasing the dosage beyond recommended levels, as one individual experienced erratic heartbeats when attempting to do so Read Review.
In general, users emphasize the importance of sticking to established guidelines for Folic Acid intake to prevent any adverse effects. The supplement is acknowledged for its role in bolstering cardiovascular health and lessening the risk of heart-related issues. Regular use, as noted by several reviewers, seems to contribute positively to heart function, making Folic Acid a valuable addition for those concerned about heart health Read Review.
6
Improves heart function
287 people found this helpful
The last time I purchased this supplement, which comes in gelatin capsules, I couldn't immediately assess the difference. I take it to support my heart and appreciate its effect. I did try increasing the dosage, but it made my heartbeat feel erratic. I am grateful to iHerb and those who leave reviews, as they significantly help me make informed choices regarding supplements when medical professionals may not always offer adequate advice.
6
Improves mood stability
1 people found this helpful
My husband noticed that during heavy exertion at the gym, he experienced a strong heartbeat. The trainer advised trying this supplement. After a course, the heart’s reaction to exercise improved. He also found that severe mood swings diminished, and the pills had a calming effect on the nervous system.
9
Reduces palpitations
1 people found this helpful
It’s for my wife; it has reduced her heart palpitations and hot flashes. Her irritability has also significantly decreased. A good quality product, and she had no complaints about the taste.
7.5
Reduces heart attack risk
1 people found this helpful
The tablets are small and easy to take. They promote new cell formation, helping my skin appear smooth and healthy, and improving the thickness and shine of my hair, as well as nail strength. Folic acid contributes to normal heart function and reduces the risk of a heart attack. With regular supplementation, a woman can maintain her youthfulness longer. I recommend it!
9
Reduces heart attack risk
Folic acid, a vitamin B, is necessary for DNA construction in body cells. It is vital for our immunity, cardiovascular health, and metabolism due to its role in amino acid synthesis. This substance bolsters blood vessel walls and supports heart health, thus lowering the risk of heart attack. It is also essential for proper nervous system function, influencing psychological mood and performance. It’s important to note that natural sources do not substitute for tablet form, as absorption is better with pills.
7.5
High-folic acid source
5 people found this helpful
Folic acid is an essential part of my daily routine, and I’m very pleased with the iHerb product. Taking 800 mcg daily promotes heart health, boosts immunity, and benefits skin health. The product came well-packaged and safe. The tablets are easy to swallow, with no unpleasant taste. I feel confident that I'm receiving the necessary nutrients for my well-being.
8
Folate intake reduces heart disease risk
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
7
Folic acid shows cardioprotection in rats
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
We investigated how folic acid (FA) might safeguard against heart damage induced by isoprenaline (ISO) in rats. Adult male Wistar albino rats received FA pretreatment for seven days before ISO was administered to mimic heart injury.
Our results showed that FA pretreatment helped reduce harmful markers indicating heart damage and oxidative stress. Specifically, FA lowered levels of homocysteine and improved antioxidant enzyme activities, suggesting a protective effect.
Ultimately, while FA demonstrated some benefits in this model, further research is needed to assess its real-world applications for heart health.
4
Folic acid shows modest stroke benefit
Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials.
We aimed to determine the effectiveness of folic acid in preventing cardiovascular disease (CVD) through an updated meta-analysis of 26 randomized controlled trials involving nearly 59,000 participants. Our findings revealed that folic acid supplementation did not significantly impact the risk of CVD, coronary heart disease, or overall mortality.
Interestingly, there was a slight trend showing potential stroke risk reduction, although results were not conclusive. Overall, while supplementation may carry some modest benefits for stroke prevention, it does not appear to significantly reduce the risk of heart-related issues.
9
Folic acid improves heart function
Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice.
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
1
No cardiovascular benefits observed
Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials.
We pooled data from two randomized controlled trials in Norway, which involved nearly 7,000 patients with ischaemic heart disease. Participants received daily doses of folic acid, vitamin B12, and other B vitamins, with a parallel group receiving a placebo.
After a thorough follow-up, we observed that there were no significant benefits of folic acid on heart attacks or other major cardiovascular events. This suggests that improving homocysteine levels through B-vitamins might not be an effective strategy for reducing heart-related risks.
References
Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. 10.1088/2057-1976/ad40b2
Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. 10.1556/2060.2023.00291
Zhang B, Dong H, Xu Y, Xu D, Sun H, et al. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort. Eur J Clin Nutr. 2023;77:299. 10.1038/s41430-022-01206-2
Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, et al. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Ann Intern Med. 2019;171:190. 10.7326/M19-0341
Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. 10.1111/joim.12834
Li H, Gao J, Shang Y, Hua Y, Ye M, et al. Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction. ACS Appl Mater Interfaces. 2018;10:24459. 10.1021/acsami.8b08659
Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612. 10.1002/14651858.CD006612.pub5
Kagawa Y, Hiraoka M, Kageyama M, Kontai Y, Yurimoto M, et al. Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification. Congenit Anom (Kyoto). 2017;57:157. 10.1111/cga.12215
Nigwekar SU, Kang A, Zoungas S, Cass A, Gallagher MP, et al. Interventions for lowering plasma homocysteine levels in dialysis patients. Cochrane Database Syst Rev. 2016;2016:CD004683. 10.1002/14651858.CD004683.pub4
Söderström E, Eliasson M, Johnson O, Hallmans G, Weinehall L, et al. Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population. Lipids Health Dis. 2013;12:74. 10.1186/1476-511X-12-74
Yang HT, Lee M, Hong KS, Ovbiagele B, Saver JL. Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials. Eur J Intern Med. 2012;23:745. 10.1016/j.ejim.2012.07.004
Mujibul Haq AM, M Giasuddin AS, Huque MM. Serum total homocysteine and lipoprotein (a) levels in acute myocardial infarction and their response to treatment with vitamins. J Coll Physicians Surg Pak. 2011;21:266.
Rautiainen S, Akesson A, Levitan EB, Morgenstern R, Mittleman MA, et al. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr. 2010;92:1251. 10.3945/ajcn.2010.29371
Qipshidze N, Tyagi N, Sen U, Givvimani S, Metreveli N, et al. Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;299:H1484. 10.1152/ajpheart.00577.2010
Ebbing M, Bønaa KH, Arnesen E, Ueland PM, Nordrehaug JE, et al. Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J Intern Med. 2010;268:367. 10.1111/j.1365-2796.2010.02259.x
Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, et al. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA. 2010;303:2486. 10.1001/jama.2010.840
Ni Y, Hua Y, He Z, Hu W, Chen Z, et al. Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction. J Biomater Appl. 2024;39:139. 10.1177/08853282241251610
An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. 10.1016/j.jacc.2022.09.048
Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
Twum F, Morte N, Wei Y, Nkemjika S, Liu F, et al. Red blood cell folate and cardiovascular deaths among hypertensive adults, an 18-year follow-up of a national cohort. Hypertens Res. 2020;43:938. 10.1038/s41440-020-0482-5
Saad Shaukat MH, Toledo-Garcia A, Torosoff M. Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C). Cureus. 2019;11:e5344. 10.7759/cureus.5344